How IVF Works, The Process Day by Day, Do's n Dont's

The literal meaning of in-vitro (in Latin) means in the glass. IVF, in vitro fertilization, means fertilization of sperm and egg in the glass, or outside the body.

The literal meaning of in-vitro (in Latin) means in the glass. IVF, in vitro fertilization, means fertilization of sperm and egg in the glass, or outside the body. IVF is indeed the foremost treatment model that has been invented to help millions of childless couples over the years. Newer technologies that are introduced are primarily to make IVF a better treatment option for couples.

IVF treatment (also known as test tube baby treatment) though may seem a little expensive but is not with better technologies and treatment options increasing the success rate. More than 1 in 5 couples need Fertility treatments to conceive. And around 8 million babies have been born to date since 1975. These “test-tube babies” are as normal as babies born through natural conception.

The In Vitro Fertilization (IVF) process can vary depending on the clinic and the patient’s individual needs. However, here is a general overview of the IVF process with a step-by-step guide from day 1 to day 30:

  • Day 1: Menstrual Cycle
    Start On the first day of your menstrual cycle, you’ll visit the clinic for a baseline evaluation, which includes blood tests and an ultrasound to check your hormone levels and the number of follicles in your ovaries.
  • Day 2-4: Ovarian Stimulation
    You’ll begin daily injections of fertility drugs to stimulate your ovaries to produce multiple eggs. You may need to continue these injections for 8-14 days, depending on your body’s response to the medication.
  • Day 5-7: Monitoring
    You’ll have regular monitoring appointments to check the development of your follicles and hormone levels. These appointments will include blood tests and ultrasounds.
  • Day 8-10: Trigger Shot
    Once your follicles have reached a certain size, you’ll receive a trigger shot to prepare your body for ovulation.
  • Day 11-12: Egg Retrieval
    About 36 hours after the trigger shot, you’ll undergo an egg retrieval procedure. You’ll receive anesthesia to ensure that you’re comfortable during the procedure, which involves using a needle to remove eggs from your ovaries.
  • Day 13-14: Fertilization After
    The egg retrieval, the eggs will be fertilized with sperm in a lab dish. This process is called insemination or ICSI (Intracytoplasmic Sperm Injection), depending on the case.
  • Day 15-19: Embryo Culture
    The fertilized eggs will be monitored in the lab for several days to allow them to develop into embryos. The embryos will be evaluated for quality and graded based on their development.
  • Day 20-21: Embryo Transfer
    On day 20-21, one or more embryos will be transferred to the uterus using a thin, flexible catheter. This is a quick and painless procedure that does not require anesthesia.
  • Day 22-30: Luteal Phase and Pregnancy Test
    After the embryo transfer, you’ll enter the luteal phase, which is the time between the transfer and the pregnancy test. During this time, you may be instructed to continue taking progesterone supplements to support the growth of the embryo.
    Two weeks after the embryo transfer, you’ll take a pregnancy test to determine if the IVF cycle was successful.

It’s important to remember that the IVF process can vary from person to person and that it may take more than one cycle to achieve a successful pregnancy. Your healthcare provider will guide you through the process and provide support and information at every step.

What is NEW?

The first successful IVF/ICSI procedure and embryo freezing took place in the 1980s. Many people have frozen embryos, only to be able to transfer them at a later time into their uterus. After egg retrieval, no embryos are transferred into the uterus but all embryos are frozen. This is referred to as a “freeze all” in IVF/ICSI treatment.

Advantages

  • Research proves that you have a better chance of getting pregnant primarily by eliminating the high hormone levels associated with ovarian stimulation, which impacts the lining of the uterus.
  • It prevents the risk of developing ovarian hyperstimulation syndrome in patients who have developed many follicles and have a high estrogen level. In other words, in Freeze All cycles, we can aim to get more eggs, thereby embryos, without worrying about OHSS.

Disadvantages

  • The first most and primary concern of doing IVF/ICSI treatment procedure and freezing embryos is that the embryo transfer is not done in the same month. This means the patient needs another month to undergo Embryo Transfer. This extends the program into two months instead of a month and may not be ideal for patients traveling from other countries.
  • The Cost of the IVF/ICSI treatment program in Pakistan will marginally increase, especially when the embryos are frozen and needed to be thawed again.
  • Psychologically this type of freeze-all IVF/ICSI treatment procedure can cause daunt on patients who are eager to get pregnant and have to keep extending it over months.

Success Rate

For the past 5 years, techniques for freezing the embryos have improved, thereby giving a slightly better chance of implanting than fresh embryos. The success rates at Zoi Fertility IVF Centre with the freeze-all technique are around 55-65% per cycle.

Reasons for freeze all IVF/ICSI treatment procedures

  • Planned freezing and storing of embryos prior to receiving chemotherapy for cancer that has direct possibility damage the eggs in the ovaries.
  • To prevent the risk of developing ovarian hyperstimulation syndrome in patients that have developed many follicles and have a high estradiol level. Ovarian stimulation syndrome is a potentially dangerous condition that is increased and worsened when a patient becomes pregnant.  By freezing the embryos and transferring them after the ovaries are no longer stimulated reduces the chances of this condition